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| カタログ番号 | HX255014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-EEF1A1 Polyclonal Antibody (HX255014) is a rabbit polyclonal antibody detecting EEF1A1 in ELISA, IHC, WB. Suitable for Human, Mouse, Cat, Rat, and Adisura bella.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human EEF1A1 (Met1-Pro241). | ||||||||
| ターゲット | EEF1A, Elongation factor Tu, Leukocyte receptor cluster member 7, Elongation factor 1-alpha 1, EF-1-alpha-1, Eukaryotic elongation factor 1 A-1, EF-Tu, EF1A, eEF1A-1, LENG7, EEF1A1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P68104 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Elongation factor 1-alpha 1 (EEF1A1) is a ~50 kDa protein. Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome. The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation. Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Also plays a role in cytoskeleton organization by promoting actin bundling. 1. Ferguson, A. et al. (2015) Molecular cell 60, 475-86. PMID: 26593721 2. Carelli, JD. et al. (2015) eLife 4. PMID: 26651998 3. Wang, HY. et al. (2022) Nature chemistry 14, 1443-1450. PMID: 36123449 4. Juette, MF. et al. (2022) eLife 11. PMID: 36264623 5. Oltion, K. et al. (2023) Cell 186, 346-362.e17. PMID: 36638793 6. Maruyama, T. et al. (2007) Clinical and experimental immunology 147, 164-75. PMID: 17177976 | ||||||||
| 注意事項 | For research use only. |
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