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| カタログ番号 | HP012014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-EMC6/TMEM93 Polyclonal Antibody (HP012014) is a rabbit polyclonal antibody detecting TMEM93 in ELISA, IHC, WB. Suitable for Bovine, Danio rerio, Human, Mouse, and Xenopus laevis.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human EMC6/TMEM93 (Val4-Thr47). | ||||||||
| ターゲット | Transmembrane protein 93, TMEM93, EMC6, ER membrane protein complex subunit 6 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9BV81 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | ER membrane protein complex subunit 6 (EMC6/TMEM93) is a ~12 kDa protein. Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. 1. Guna, A. et al. (2018) Science (New York, N.Y.) 359, 470-473. PMID: 29242231 2. Shurtleff, MJ. et al. (2018) eLife 7. PMID: 29809151 3. Chitwood, PJ. et al. (2018) Cell 175, 1507-1519.e16. PMID: 30415835 4. Pleiner, T. et al. (2020) Science (New York, N.Y.) 369, 433-436. PMID: 32439656 5. O'Donnell, JP. et al. (2020) eLife 9. PMID: 32459176 | ||||||||
| 注意事項 | For research use only. |
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