Anti-EMC6/TMEM93 Polyclonal Antibody (HP012014)

Name: Anti-EMC6/TMEM93 Polyclonal Antibody
Brand: abinScience
SKU: HP012014
Price: 168 USD
Availability: InStock

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Обзор

Каталожный номер

HP012014

Описание

Anti-EMC6/TMEM93 Polyclonal Antibody (HP012014) is a rabbit polyclonal antibody detecting TMEM93 in ELISA, IHC, WB. Suitable for Bovine, Danio rerio, Human, Mouse, and Xenopus laevis.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human EMC6/TMEM93 (Val4-Thr47).

Цель

Transmembrane protein 93, TMEM93, EMC6, ER membrane protein complex subunit 6

Очистка

Purified by antigen affinity column.

Номер доступа

Q9BV81

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

ER membrane protein complex subunit 6 (EMC6/TMEM93) is a ~12 kDa protein. Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors.

1. Guna, A. et al. (2018) Science (New York, N.Y.) 359, 470-473. PMID: 29242231

2. Shurtleff, MJ. et al. (2018) eLife 7. PMID: 29809151

3. Chitwood, PJ. et al. (2018) Cell 175, 1507-1519.e16. PMID: 30415835

4. Pleiner, T. et al. (2020) Science (New York, N.Y.) 369, 433-436. PMID: 32439656

5. O'Donnell, JP. et al. (2020) eLife 9. PMID: 32459176

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-EMC6/TMEM93 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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