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| カタログ番号 | HB668014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ERCC5 Polyclonal Antibody (HB668014) is a rabbit polyclonal antibody detecting ERCC5 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ERCC5 (Leu778-Ala986). | ||||||||
| ターゲット | ERCC5, DNA excision repair protein ERCC-5, ERCM2, XPGC, Xeroderma pigmentosum group G-complementing protein, XPG, DNA repair protein complementing XP-G cells | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P28715 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | DNA excision repair protein ERCC-5 (ERCC5) is a ~133 kDa protein. Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble. Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA. Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. 1. Tsutakawa, SE. et al. (2020) Proceedings of the National Academy of Sciences of the United States of America 117, 14127-14138. PMID: 32522879 2. González-Corrochano, R. et al. (2020) Nucleic acids research 48, 9943-9958. PMID: 32821917 3. Cloud, KG. et al. (1995) Mutation research 347, 55-60. PMID: 7651464 4. Habraken, Y. et al. (1994) Nucleic acids research 22, 3312-6. PMID: 8078765 5. O'Donovan, A. et al. (1994) Nature 371, 432-5. PMID: 8090225 6. O'Donovan, A. et al. (1994) The Journal of biological chemistry 269, 15965-8. PMID: 8206890 7. Bessho, T. (1999) Nucleic acids research 27, 979-83. PMID: 9927729 8. Sarker, AH. et al. (2005) Molecular cell 20, 187-98. PMID: 16246722 10. Kokic, G. et al. (2019) Nature communications 10, 2885. PMID: 31253769 | ||||||||
| 注意事項 | For research use only. |
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