中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HF610014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-F10/Factor X Polyclonal Antibody (HF610014) is a rabbit polyclonal antibody detecting F10 in ELISA, IHC, WB. Suitable for Human.
Highlights
|
||||||||
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human F10/Factor X (Leu24-Lys488). | ||||||||
| ターゲット | Stuart factor, Stuart-Prower factor, Coagulation factor X, F10 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P00742 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Coagulation factor X (F10) is a ~54 kDa protein. Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. Factor Xa activates pro-inflammatory signaling pathways in a protease-activated receptor (PAR)-dependent manner. Up-regulates expression of protease-activated receptors (PARs) F2R, F2RL1 and F2RL2 in dermal microvascular endothelial cells. Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, in cardiac fibroblasts and umbilical vein endothelial cells in PAR-1/F2R-dependent manner. Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2, IL6, TNF/TNF, IL-1beta/IL1B, IL8/CXCL8 and IL18, in endothelial cells and atrial tissues. 1. Manithody, C. et al. (2012) Biochemistry 51, 2551-7. PMID: 22409427 2. Cao, Q. et al. (2025) Nature 639, 816-824. PMID: 39880037 3. Bukowska, A. et al. (2013) European journal of pharmacology 718, 114-23. PMID: 24041930 4. Shinozawa, E. et al. (2018) Frontiers in pharmacology 9, 1431. PMID: 30568593 5. D'Alessandro, E. et al. (2021) Cells 10. PMID: 34831181 6. Borensztajn, K. et al. (2008) The American journal of pathology 172, 309-20. PMID: 18202198 7. Shrivastava, G. et al. (2022) ImmunoHorizons 6, 373-383. PMID: 35738824 8. Senden, NH. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 161, 4318-24. PMID: 9780208 | ||||||||
| 注意事項 | For research use only. |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
