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| カタログ番号 | HC114013 |
|---|---|
| 説明 |
Anti-G protein Nanobody (Nb35) [Nb35] (HC114013) is a alpaca monoclonal antibody detecting G protein in Cyro-EM, X-ray Crystallography. Suitable for Human.
|
| 種反応性 | Human |
| アプリケーション | Cyro-EM, X-ray Crystallography |
| 宿主種 | Alpaca |
| クローン性 | Monoclonal |
| アイソタイプ | VHH-His |
| クローンID | Nb35 |
| ターゲット | G protein |
| エンドトキシンレベル | <0.01 EU/ug |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Purified by Nickel column. |
| アクセッション番号 | P63092 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | Nanobody 35, Nanobody-35, Nb-35 |
| 背景 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short is a ~45 kDa protein. Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. 1. Pak, Y. et al. (2002) Molecular and cellular biology 22, 7942-52. PMID: 12391161 2. Gao, X. et al. (2007) The Journal of biological chemistry 282, 294-302. PMID: 17110384 3. Thiele, S. et al. (2011) Human mutation 32, 653-60. PMID: 21488135 4. Brand, CS. et al. (2015) Molecular pharmacology 88, 758-67. PMID: 26206488 5. Farfel, Z. et al. (1996) The Journal of biological chemistry 271, 19653-5. PMID: 8702665 6. Warner, DR. et al. (1999) Proceedings of the National Academy of Sciences of the United States of America 96, 4268-72. PMID: 10200251 |
| 注意事項 | For research use only |
SDS-PAGE for Anti-G protein Nanobody (Nb35)
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