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| カタログ番号 | HW551014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-GPX4 Polyclonal Antibody (HW551014) is a rabbit polyclonal antibody detecting GPX4 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Callithrix jacchus.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human GPX4 (Gly73-Phe196). | ||||||||
| ターゲット | PHGPx, Glutathione peroxidase 4, GPX4, GSHPx-4, GPx-4, Phospholipid hydroperoxide glutathione peroxidase | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P36969 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Phospholipid hydroperoxide glutathione peroxidase GPX4 (PHGPx) is a ~22 kDa protein. Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins. Can also reduce cholesterol hydroperoxide and thymine hydroperoxide. Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species. The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis. 1. Zheng, P. et al. (2025) Nature chemical biology 21, 1420-1432. PMID: 40281343 2. Yang, WS. et al. (2014) Cell 156, 317-331. PMID: 24439385 3. Sutherland, M. et al. (2001) The Biochemical journal 353, 91-100. PMID: 11115402 4. Schwarz, M. et al. (2023) Redox biology 59, 102593. PMID: 36608588 5. Scheerer, P. et al. (2007) Biochemistry 46, 9041-9. PMID: 17630701 | ||||||||
| 注意事項 | For research use only. |
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