Anti-Human GPX4 Polyclonal Antibody (HW551014)

Name: Anti-Human GPX4 Polyclonal Antibody
Brand: abinScience
SKU: HW551014
Price: 168 USD
Availability: InStock

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Спецификация:

50ug
100ug

Количество:

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Каталожный номер

HW551014

Описание

Anti-GPX4 Polyclonal Antibody (HW551014) is a rabbit polyclonal antibody detecting GPX4 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Callithrix jacchus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human GPX4 (Gly73-Phe196).

Цель

PHGPx, Glutathione peroxidase 4, GPX4, GSHPx-4, GPx-4, Phospholipid hydroperoxide glutathione peroxidase

Уровень эндотоксинов

Please contact with the lab for this information.

Чистота

>95% as determined by SDS-PAGE.

Очистка

Purified by antigen affinity column.

Номер доступа

P36969

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Phospholipid hydroperoxide glutathione peroxidase GPX4 (PHGPx) is a ~22 kDa protein. Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins. Can also reduce cholesterol hydroperoxide and thymine hydroperoxide. Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species. The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis.

1. Zheng, P. et al. (2025) Nature chemical biology 21, 1420-1432. PMID: 40281343

2. Yang, WS. et al. (2014) Cell 156, 317-331. PMID: 24439385

3. Sutherland, M. et al. (2001) The Biochemical journal 353, 91-100. PMID: 11115402

4. Schwarz, M. et al. (2023) Redox biology 59, 102593. PMID: 36608588

5. Scheerer, P. et al. (2007) Biochemistry 46, 9041-9. PMID: 17630701

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human GPX4 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-Human GPX4 Polyclonal Antibody (HW551014)

Обзор

Изображения

Ссылки

Даташит

SDS