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| カタログ番号 | HX194014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-GRB2 Polyclonal Antibody (HX194014) is a rabbit polyclonal antibody detecting GRB2 in ELISA, IHC, WB. Suitable for Chicken, Human, Mouse, Pongo abelii, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human GRB2 (Met1-Val217). | ||||||||
| ターゲット | Protein Ash, GRB2, Growth factor receptor-bound protein 2, SH2/SH3 adapter GRB2, ASH, Adapter protein GRB2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P62993 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Growth factor receptor-bound protein 2 (GRB2) is a ~25 kDa protein. Non-enzymatic adapter protein that plays a pivotal role in precisely regulated signaling cascades from cell surface receptors to cellular responses, including signaling transduction and gene expression. Thus, participates in many biological processes including regulation of innate and adaptive immunity, autophagy, DNA repair or necroptosis. Controls signaling complexes at the T-cell antigen receptor to facilitate the activation, differentiation, and function of T-cells. Mechanistically, engagement of the TCR leads to phosphorylation of the adapter protein LAT, which serves as docking site for GRB2. In turn, GRB2 establishes a a connection with SOS1 that acts as a guanine nucleotide exchange factor and serves as a critical regulator of KRAS/RAF1 leading to MAPKs translocation to the nucleus and activation. 1. Li, S. et al. (2001) The EMBO journal 20, 6793-804. PMID: 11726515 2. Zhou, J. et al. (2023) Cell communication and signaling : CCS 21, 224. PMID: 37626338 3. Hou, B. et al. (2022) Cell death discovery 8, 319. PMID: 35831301 4. Montero-Vergara, J. et al. (2024) Cell death & disease 15, 14. PMID: 38182563 5. Sandouk, A. et al. (2023) Scientific reports 13, 3505. PMID: 36864087 6. Zhang, W. et al. (1998) Cell 92, 83-92. PMID: 9489702 7. Wu, L. et al. (2002) The Journal of biological chemistry 277, 40420-7. PMID: 12171928 8. Bilal, MY. et al. (2015) Frontiers in immunology 6, 141. PMID: 25870599 10. Vanshylla, K. et al. (2018) Scientific reports 8, 4244. PMID: 29523808 | ||||||||
| 注意事項 | For research use only. |
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