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Anti-GRIK2 Polyclonal Antibody (HC267014)

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Aperçu
Numéro de catalogueHC267014
Description
Anti-GRIK2 Polyclonal Antibody (HC267014) is a rabbit polyclonal antibody detecting GRIK2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human GRIK2 (Asn286-Pro561).
Cible EAA4, GluR6, Glutamate receptor 6, Excitatory amino acid receptor 4, Glutamate receptor ionotropic, kainate 2, GluK2, GLUR6, GRIK2, GluR-6
Purification Purified by antigen affinity column.
Numéro d'accès Q13002
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Glutamate receptor ionotropic, kainate 2 (GRIK2) is a ~102 kDa protein. Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformational change leading to the opening of the cation channel, converting the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. Modulates cell surface expression of NETO2.

1. Hoo, KH. et al. (1994) Receptors & channels 2, 327-37. PMID: 7536611
2. Swanson, GT. et al. (1996) The Journal of physiology 492 ( Pt 1), 129-42. PMID: 8730589
3. Hayes, DM. et al. (2003) Biochemical and biophysical research communications 310, 8-13. PMID: 14511640
4. Guzmán, YF. et al. (2017) Neurology. Genetics 3, e129. PMID: 28180184
5. Stolz, JR. et al. (2021) American journal of human genetics 108, 1692-1709. PMID: 34375587
Note For research use only.
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Reférences
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-GRIK2 Polyclonal Antibody

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