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| カタログ番号 | HC267014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-GRIK2 Polyclonal Antibody (HC267014) is a rabbit polyclonal antibody detecting GRIK2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human GRIK2 (Asn286-Pro561). | ||||||||
| ターゲット | EAA4, GluR6, Glutamate receptor 6, Excitatory amino acid receptor 4, Glutamate receptor ionotropic, kainate 2, GluK2, GLUR6, GRIK2, GluR-6 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13002 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Glutamate receptor ionotropic, kainate 2 (GRIK2) is a ~102 kDa protein. Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformational change leading to the opening of the cation channel, converting the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. Modulates cell surface expression of NETO2. 1. Hoo, KH. et al. (1994) Receptors & channels 2, 327-37. PMID: 7536611 2. Swanson, GT. et al. (1996) The Journal of physiology 492 ( Pt 1), 129-42. PMID: 8730589 3. Hayes, DM. et al. (2003) Biochemical and biophysical research communications 310, 8-13. PMID: 14511640 4. Guzmán, YF. et al. (2017) Neurology. Genetics 3, e129. PMID: 28180184 5. Stolz, JR. et al. (2021) American journal of human genetics 108, 1692-1709. PMID: 34375587 | ||||||||
| 注意事項 | For research use only. |
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