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Anti-GRK2 Polyclonal Antibody (HB035014)

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Aperçu
Numéro de catalogueHB035014
Description
Anti-GRK2 Polyclonal Antibody (HB035014) is a rabbit polyclonal antibody detecting GRK2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human GRK2 (Asp398-Leu640).
Cible G-protein coupled receptor kinase 2, GRK2, ADRBK1, Beta-adrenergic receptor kinase 1, BARK1, BARK, Beta-ARK-1
Purification Purified by antigen affinity column.
Numéro d'accès P25098
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Beta-adrenergic receptor kinase 1 (GRK2) is a ~79 kDa protein. Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Phosphorylates catecholamine-activated ADRB2 to regulate physiological cardiomyocyte contraction rate responses. Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor.

1. Pao, CS. et al. (2009) Biochemistry 48, 7325-33. PMID: 19715378
2. Guo, Q. et al. (2011) PloS one 6, e22559. PMID: 21799898
3. Gupta, K. et al. (2012) PloS one 7, e46369. PMID: 23077507
4. Aziziyeh, AI. et al. (2009) Cellular signalling 21, 1207-17. PMID: 19306925
5. Yim, PD. et al. (2019) American journal of physiology. Lung cellular and molecular physiology 316, L82-L93. PMID: 30284927
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-GRK2 Polyclonal Antibody

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