

| Каталожный номер | HB035014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-GRK2 Polyclonal Antibody (HB035014) is a rabbit polyclonal antibody detecting GRK2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human GRK2 (Asp398-Leu640). | ||||||||
| Цель | G-protein coupled receptor kinase 2, GRK2, ADRBK1, Beta-adrenergic receptor kinase 1, BARK1, BARK, Beta-ARK-1 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P25098 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Beta-adrenergic receptor kinase 1 (GRK2) is a ~79 kDa protein. Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Phosphorylates catecholamine-activated ADRB2 to regulate physiological cardiomyocyte contraction rate responses. Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. 1. Pao, CS. et al. (2009) Biochemistry 48, 7325-33. PMID: 19715378 2. Guo, Q. et al. (2011) PloS one 6, e22559. PMID: 21799898 3. Gupta, K. et al. (2012) PloS one 7, e46369. PMID: 23077507 4. Aziziyeh, AI. et al. (2009) Cellular signalling 21, 1207-17. PMID: 19306925 5. Yim, PD. et al. (2019) American journal of physiology. Lung cellular and molecular physiology 316, L82-L93. PMID: 30284927 | ||||||||
| Примечание | For research use only. |
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