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Anti-GRN Polyclonal Antibody (HB264014)

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Vista general
Número de catálogoHB264014
Descripción
Anti-GRN Polyclonal Antibody (HB264014) is a rabbit polyclonal antibody detecting GRN in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human GRN (Thr18-Asp363).
Objetivo PC cell-derived growth factor, Granulin G, Epithelin precursor, Epithelin-1, Granulin A, Acrogranin, Progranulin, Granulin F, Proepithelin, PGRN, Glycoprotein of 88 Kda, GRN, Granulin C, Granulin E, Granulin precursor, PEPI, PCDGF, Granulin D, Glycoprotein 88, Epithelin-2, GP88, Granulin B
Purificación Purified by antigen affinity column.
Número de acceso P28799
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Progranulin (GP88/GRN) is a ~63 kDa protein. Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes. Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases.

1. Zhu, J. et al. (2002) Cell 111, 867-78. PMID: 12526812
2. Van Damme, P. et al. (2008) The Journal of cell biology 181, 37-41. PMID: 18378771
3. Tanaka, Y. et al. (2017) Human molecular genetics 26, 969-988. PMID: 28073925
4. Beel, S. et al. (2017) Human molecular genetics 26, 2850-2863. PMID: 28453791
5. Zhou, X. et al. (2017) Nature communications 8, 15277. PMID: 28541286
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-GRN Polyclonal Antibody

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