Anti-Human GP88/GRN Reference Antibody (AG1, RUO) (HB264016)

Name: Anti-Human GP88/GRN Reference Antibody (AG1, RUO)
Brand: abinScience
SKU: HB264016
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HB264016
Description	Anti-Human GP88/GRN (AG1) (HB264016) is a research-grade recombinant antibody targeting PC cell-derived growth factor. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Clonality	Monoclonal
Isotype	IgG
Clone ID	AG1
Expression system	Mammalian cells
Target	PC cell-derived growth factor, Granulin G, Epithelin precursor, Epithelin-1, Granulin A, Acrogranin, Progranulin, Granulin F, Proepithelin, PGRN, Glycoprotein of 88 Kda, GRN, Granulin C, Granulin E, Granulin precursor, PEPI, PCDGF, Granulin D, Glycoprotein 88, Epithelin-2, GP88, Granulin B
Endotoxin level	< 10 EU/mg
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P28799
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	AG1
Background	Progranulin (GP88/GRN) is a ~63 kDa protein. Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes. Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases. 1. Zhu, J. et al. (2002) Cell 111, 867-78. PMID: 12526812 2. Van Damme, P. et al. (2008) The Journal of cell biology 181, 37-41. PMID: 18378771 3. Tanaka, Y. et al. (2017) Human molecular genetics 26, 969-988. PMID: 28073925 4. Beel, S. et al. (2017) Human molecular genetics 26, 2850-2863. PMID: 28453791 5. Zhou, X. et al. (2017) Nature communications 8, 15277. PMID: 28541286
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

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SDS-PAGE for Research Grade Anti-Human GP88/GRN (AG1)

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Anti-Human GP88/GRN Reference Antibody (AG1, RUO).pdf

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Anti-Human GP88/GRN Reference Antibody (AG1, RUO) (HB264016)

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