Anti-GRN Polyclonal Antibody (HB264014)

Name: Anti-GRN Polyclonal Antibody
Brand: abinScience
SKU: HB264014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HB264014

Description

Anti-GRN Polyclonal Antibody (HB264014) is a rabbit polyclonal antibody detecting GRN in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human GRN (Thr18-Asp363).

Cible

PC cell-derived growth factor, Granulin G, Epithelin precursor, Epithelin-1, Granulin A, Acrogranin, Progranulin, Granulin F, Proepithelin, PGRN, Glycoprotein of 88 Kda, GRN, Granulin C, Granulin E, Granulin precursor, PEPI, PCDGF, Granulin D, Glycoprotein 88, Epithelin-2, GP88, Granulin B

Purification

Purified by antigen affinity column.

Numéro d'accès

P28799

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Progranulin (GP88/GRN) is a ~63 kDa protein. Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes. Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases.

1. Zhu, J. et al. (2002) Cell 111, 867-78. PMID: 12526812

2. Van Damme, P. et al. (2008) The Journal of cell biology 181, 37-41. PMID: 18378771

3. Tanaka, Y. et al. (2017) Human molecular genetics 26, 969-988. PMID: 28073925

4. Beel, S. et al. (2017) Human molecular genetics 26, 2850-2863. PMID: 28453791

5. Zhou, X. et al. (2017) Nature communications 8, 15277. PMID: 28541286

Note

For research use only.

Images

Reférences

Fiche technique

Anti-GRN Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

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