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| カタログ番号 | HB264014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-GRN Polyclonal Antibody (HB264014) is a rabbit polyclonal antibody detecting GRN in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human GRN (Thr18-Asp363). | ||||||||
| ターゲット | PC cell-derived growth factor, Granulin G, Epithelin precursor, Epithelin-1, Granulin A, Acrogranin, Progranulin, Granulin F, Proepithelin, PGRN, Glycoprotein of 88 Kda, GRN, Granulin C, Granulin E, Granulin precursor, PEPI, PCDGF, Granulin D, Glycoprotein 88, Epithelin-2, GP88, Granulin B | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P28799 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Progranulin (GP88/GRN) is a ~63 kDa protein. Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes. Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases. 1. Zhu, J. et al. (2002) Cell 111, 867-78. PMID: 12526812 2. Van Damme, P. et al. (2008) The Journal of cell biology 181, 37-41. PMID: 18378771 3. Tanaka, Y. et al. (2017) Human molecular genetics 26, 969-988. PMID: 28073925 4. Beel, S. et al. (2017) Human molecular genetics 26, 2850-2863. PMID: 28453791 5. Zhou, X. et al. (2017) Nature communications 8, 15277. PMID: 28541286 | ||||||||
| 注意事項 | For research use only. |
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