Anti-HAT1 Polyclonal Antibody (HD437014)

Name: Anti-HAT1 Polyclonal Antibody
Brand: abinScience
SKU: HD437014
Price: 96 USD
Availability: InStock

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20ug
50ug
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Número de catálogo

HD437014

Descripción

Anti-HAT1 Polyclonal Antibody (HD437014) is a rabbit polyclonal antibody detecting HAT1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human HAT1 (Met1-Glu419).

Objetivo

EC:2.3.1.48, HAT1, Histone acetyltransferase 1, Histone acetyltransferase type B catalytic subunit, KAT1

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

O14929

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Nombres alternativos

O14929

Fondo

Histone acetyltransferase type B catalytic subunit (HAT1) is a ~49 kDa protein. Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression.

1. Campos, EI. et al. (2010) Nature structural & molecular biology 17, 1343-51. PMID: 20953179

2. Yang, X. et al. (2013) The Journal of biological chemistry 288, 18271-82. PMID: 23653357

3. Gruber, JJ. et al. (2019) Molecular cell 75, 711-724.e5. PMID: 31278053

4. Agudelo Garcia, PA. et al. (2020) Journal of proteome research 19, 1663-1673. PMID: 32081014

5. Makowski, AM. et al. (2001) The Journal of biological chemistry 276, 43499-502. PMID: 11585814

6. Wu, H. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 8925-30. PMID: 22615379

7. Yuan, Y. et al. (2020) Molecular cell 77, 734-747.e7. PMID: 31812350

Nota

For research use only

Imágenes

Western blot

Western blot analysis was performed using anti-HAT1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: MDA-MB-231 cell lysate
Lane 2: Hela cell lysate
Lane 3: HepG2 cell lysate
Lane 4: 293T cell lysate
Lane 5: Lncap cell lysate
Lane 6: K562 cell lysate
Lane 7: PC-12 cell lysate

Referencias

Datasheet

Anti-HAT1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-HAT1 Polyclonal Antibody (HD437014)

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Imágenes

Referencias

Datasheet

SDS