Human HAT1 Recombinant Protein (N-His) (HD437012)

Name: Human HAT1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD437012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD437012
Description	Recombinant Human HAT1 Protein, N-His (HD437012) expressed in E. coli, spanning Met1-Glu419. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	O14929
Protein length	Met1-Glu419
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	51.68 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:2.3.1.48, HAT1, Histone acetyltransferase 1, Histone acetyltransferase type B catalytic subunit, KAT1
Background	Histone acetyltransferase type B catalytic subunit is a ~49 kDa protein. Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression. 1. Campos, EI. et al. (2010) Nature structural & molecular biology 17, 1343-51. PMID: 20953179 2. Yang, X. et al. (2013) The Journal of biological chemistry 288, 18271-82. PMID: 23653357 3. Gruber, JJ. et al. (2019) Molecular cell 75, 711-724.e5. PMID: 31278053 4. Agudelo Garcia, PA. et al. (2020) Journal of proteome research 19, 1663-1673. PMID: 32081014 5. Makowski, AM. et al. (2001) The Journal of biological chemistry 276, 43499-502. PMID: 11585814 6. Wu, H. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 8925-30. PMID: 22615379 7. Yuan, Y. et al. (2020) Molecular cell 77, 734-747.e7. PMID: 31812350
Note	For research use only

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Datasheet

Human HAT1 Recombinant Protein (N-His).pdf

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Human HAT1 Recombinant Protein (N-His) (HD437012)

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