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| カタログ番号 | HD437014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-HAT1 Polyclonal Antibody (HD437014) is a rabbit polyclonal antibody detecting HAT1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human HAT1 (Met1-Glu419). | ||||||||
| ターゲット | EC:2.3.1.48, HAT1, Histone acetyltransferase 1, Histone acetyltransferase type B catalytic subunit, KAT1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O14929 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 別名 | O14929 | ||||||||
| 背景 | Histone acetyltransferase type B catalytic subunit (HAT1) is a ~49 kDa protein. Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression. 1. Campos, EI. et al. (2010) Nature structural & molecular biology 17, 1343-51. PMID: 20953179 2. Yang, X. et al. (2013) The Journal of biological chemistry 288, 18271-82. PMID: 23653357 3. Gruber, JJ. et al. (2019) Molecular cell 75, 711-724.e5. PMID: 31278053 4. Agudelo Garcia, PA. et al. (2020) Journal of proteome research 19, 1663-1673. PMID: 32081014 5. Makowski, AM. et al. (2001) The Journal of biological chemistry 276, 43499-502. PMID: 11585814 6. Wu, H. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 8925-30. PMID: 22615379 7. Yuan, Y. et al. (2020) Molecular cell 77, 734-747.e7. PMID: 31812350 | ||||||||
| 注意事項 | For research use only |
Western blot analysis was performed using anti-HAT1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: MDA-MB-231 cell lysate
Lane 2: Hela cell lysate
Lane 3: HepG2 cell lysate
Lane 4: 293T cell lysate
Lane 5: Lncap cell lysate
Lane 6: K562 cell lysate
Lane 7: PC-12 cell lysate
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