

| Numéro de catalogue | VK420014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reactivité des espèces | Human metapneumovirus (HMPV) | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant HMPV M2/Protein M2-2 (Thr2-Ser71). | ||||||||
| Cible | Protein M2-2, M2 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q6WB96 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Protein M2-2 is a ~8 kDa protein. Mediates the regulatory switch from transcription to RNA replication. Acts late in infection by inhibiting viral transcription and up-regulating RNA replication. Plays a major role in antagonizing the type I IFN-mediated antiviral response. Interacts with host MAVS and prevents the interaction with its upstream partner RIGI in the signaling pathway leading to interferon production. Inhibits host RIGI signaling by preventing TRIM25-mediated RIGI ubiquitination. 1. Ren, J. et al. (2012) Journal of virology 86, 13049-61. PMID: 23015697 2. Tanaka, Y. et al. (2022) Frontiers in immunology 13, 970750. PMID: 36045682 3. Ren, J. et al. (2014) PloS one 9, e91865. PMID: 24618691 4. Kitagawa, Y. et al. (2017) Journal of virology 91. PMID: 28768858 | ||||||||
| Note | For research use only. |
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