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| カタログ番号 | VK420014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human metapneumovirus (HMPV) | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant HMPV M2/Protein M2-2 (Thr2-Ser71). | ||||||||
| ターゲット | Protein M2-2, M2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q6WB96 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Protein M2-2 is a ~8 kDa protein. Mediates the regulatory switch from transcription to RNA replication. Acts late in infection by inhibiting viral transcription and up-regulating RNA replication. Plays a major role in antagonizing the type I IFN-mediated antiviral response. Interacts with host MAVS and prevents the interaction with its upstream partner RIGI in the signaling pathway leading to interferon production. Inhibits host RIGI signaling by preventing TRIM25-mediated RIGI ubiquitination. 1. Ren, J. et al. (2012) Journal of virology 86, 13049-61. PMID: 23015697 2. Tanaka, Y. et al. (2022) Frontiers in immunology 13, 970750. PMID: 36045682 3. Ren, J. et al. (2014) PloS one 9, e91865. PMID: 24618691 4. Kitagawa, Y. et al. (2017) Journal of virology 91. PMID: 28768858 | ||||||||
| 注意事項 | For research use only. |
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