Anti-Honeybee Api m 11/MRJP1 Polyclonal Antibody (ZA222014)

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Major royal jelly protein 1 (Api m 11/MRJP1) is a ~48 kDa protein. Most abundant protein component of royal jelly, a substance produced in the hypopharyngeal gland containing proteins, free amino acids, fatty acids, sugars and other nutrients, which is fed to developing larvae by worker nurse bees. Major royal jelly proteins (Mrjps) are high in essential amino acids and probably have a nutritional function in larval food. All larvae are fed some royal jelly (also known as worker jelly) early in their development but it forms the principal source of nutrition for larvae destined to become queen bees (Probable). Induces the differentiation of honey bee larvae into queens through an Egfr-mediated signaling pathway. Promotes body size increase by activating p70 S6 kinase, stimulates ovary development by augmenting the titer of vitellogenin (Vg) and juvenile hormone, and reduces developmental time by increasing the activity of mitogen-activated protein kinase and inducing 20-hydroxyecdysone (ecdysterone, 20E) production.