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| カタログ番号 | VK081024 | ||||||||
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| 説明 |
Anti-HSV-2/HHV-2 glycoprotein H/gH Polyclonal Antibody (VK081024) is a rabbit polyclonal antibody detecting HSV-2/HHV-2 glycoprotein H/gH. Suitable for Human herpesvirus 2.
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| 種反応性 | Human herpesvirus 2 (HHV-2) (Human herpes simplex virus 2) (HSV-2) | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant HSV-2/HHV-2 glycoprotein H/gH (Arg49-Pro803). | ||||||||
| ターゲット | Envelope glycoprotein H, gH | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P89445 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Envelope glycoprotein H (gH) is a ~89 kDa protein. The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis. Interaction with host integrins ITGAV/ITGB3 triggers release of cytosolic Ca(2+) and FAK phosphorylation leading to efficient viral entry into host genital tract epithelial cells. 1. Cheshenko, N. et al. (2014) Journal of virology 88, 10026-38. PMID: 24942591 | ||||||||
| 注意事項 | For research use only. |
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