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Anti-HTLV-1 Tax Polyclonal Antibody (VK044014)

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Aperçu
Numéro de catalogueVK044014
Description
Anti-HTLV-1 Tax Polyclonal Antibody (VK044014) is a rabbit polyclonal antibody detecting Protein Tax-1 in ELISA, IHC, WB.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesHuman T-cell leukemia virus 1 (HTLV-1)
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant HTLV-1 Tax (Gly26-Pro224).
Cible Protein Tax-1, Protein X-LOR, Protein PX, Trans-activating transcriptional regulatory protein of HTLV-1, Tax
Niveau d'endotoxines Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Numéro d'accès P03409
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Protein Tax-1 is a ~39 kDa protein. Transcriptional activator that governs the viral transcription from the 5'LTR via the recruitment of dimers of host phosphorylated CREB1. Together they bind cAMP response elements within the viral promoter and mediate high-level viral transcription. Increases host CREB1 O-GlcNAcylation to further increase 5'LTR transactivation. Modulates also the expression of cellular genes leading to the deregulation of T-cell proliferation, perturbing the integrity of cell cycle checkpoints, the DNA damage response and apopototic pathways. Acts as an ubiquitin E3 ligase and stimulates host IKK complex by catalyzing the assembly of free mixed-linkage polyubiquitin chains, resulting in constitutive activation of the transcription factor NF-kappa-B.

1. Kusano, S. et al. (2012) Virology 432, 343-52. PMID: 22789739
2. Tie, F. et al. (1996) Journal of virology 70, 8368-74. PMID: 8970957
3. Groussaud, D. et al. (2017) PLoS pathogens 13, e1006518. PMID: 28742148
4. Wang, C. et al. (2016) PLoS pathogens 12, e1005584. PMID: 27082114
5. Shibata, Y. et al. (2017) PLoS pathogens 13, e1006162. PMID: 28103322
Note For research use only
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Reférences
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-HTLV-1 Tax Polyclonal Antibody

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