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| カタログ番号 | VK044014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-HTLV-1 Tax Polyclonal Antibody (VK044014) is a rabbit polyclonal antibody detecting Protein Tax-1 in ELISA, IHC, WB.
Highlights
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| 種反応性 | Human T-cell leukemia virus 1 (HTLV-1) | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant HTLV-1 Tax (Gly26-Pro224). | ||||||||
| ターゲット | Protein Tax-1, Protein X-LOR, Protein PX, Trans-activating transcriptional regulatory protein of HTLV-1, Tax | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P03409 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Protein Tax-1 is a ~39 kDa protein. Transcriptional activator that governs the viral transcription from the 5'LTR via the recruitment of dimers of host phosphorylated CREB1. Together they bind cAMP response elements within the viral promoter and mediate high-level viral transcription. Increases host CREB1 O-GlcNAcylation to further increase 5'LTR transactivation. Modulates also the expression of cellular genes leading to the deregulation of T-cell proliferation, perturbing the integrity of cell cycle checkpoints, the DNA damage response and apopototic pathways. Acts as an ubiquitin E3 ligase and stimulates host IKK complex by catalyzing the assembly of free mixed-linkage polyubiquitin chains, resulting in constitutive activation of the transcription factor NF-kappa-B. 1. Kusano, S. et al. (2012) Virology 432, 343-52. PMID: 22789739 2. Tie, F. et al. (1996) Journal of virology 70, 8368-74. PMID: 8970957 3. Groussaud, D. et al. (2017) PLoS pathogens 13, e1006518. PMID: 28742148 4. Wang, C. et al. (2016) PLoS pathogens 12, e1005584. PMID: 27082114 5. Shibata, Y. et al. (2017) PLoS pathogens 13, e1006162. PMID: 28103322 | ||||||||
| 注意事項 | For research use only |
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