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| カタログ番号 | HV570014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ABCB10 (Leu492-Ala738). | ||||||||
| ターゲット | M-ABC2, ABC transporter 10 protein, Mitochondrial ATP-binding cassette 2, ATP-binding cassette sub-family B member 10, mitochondrial, ABCB10, ATP-binding cassette transporter 10 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9NRK6 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | ATP-binding cassette sub-family B member 10, mitochondrial (ABCB10) is a ~79 kDa protein. ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress. Participates in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). Involved in the stabilization of the iron transporter mitoferrin-1/SLC25A37. In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria. 1. Tang, L. et al. (2012) British journal of haematology 157, 151-4. PMID: 22085049 2. Yano, M. (2017) Biochemical and biophysical research communications 486, 465-469. PMID: 28315685 3. Seguin, A. et al. (2017) The Journal of biological chemistry 292, 16284-16299. PMID: 28808058 4. Shum, M. et al. (2021) Science translational medicine 13. PMID: 34011630 5. Cao, S. et al. (2023) Nature communications 14, 2030. PMID: 37041204 | ||||||||
| 注意事項 | For research use only. |
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