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| カタログ番号 | HF994013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1534 | ||||
| ターゲット | BSEP, Bile salt export pump, ABCB11, ATP-binding cassette sub-family B member 11 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | O95342 | ||||
| RRID | Anti-Human ABCB11 Antibody (SAA1534) (abinScience Cat# HF994013, RRID:AB_3727295) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Bile salt export pump (ABCB11) is a ~146 kDa protein. Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion. 1. Hayashi, H. et al. (2005) Hepatology (Baltimore, Md.) 41, 916-24. PMID: 15791618 2. Hayashi, H. et al. (2005) Biochimica et biophysica acta 1738, 54-62. PMID: 16332456 3. Yabuuchi, H. et al. (2008) Biopharmaceutics & drug disposition 29, 441-8. PMID: 18985798 4. Paulusma, CC. et al. (2009) The Journal of biological chemistry 284, 9947-54. PMID: 19228692 5. Ho, RH. et al. (2010) Pharmacogenetics and genomics 20, 45-57. PMID: 20010382 6. Kato, T. et al. (2010) Biochimica et biophysica acta 1801, 1005-12. PMID: 20398791 7. Hayashi, H. et al. (2012) Hepatology (Baltimore, Md.) 55, 1889-900. PMID: 22262466 8. Guyot, C. et al. (2014) Molecular pharmacology 85, 909-20. PMID: 24711118 9. Imagawa, K. et al. (2018) Journal of human genetics 63, 569-577. PMID: 29507376 10. Wang, L. et al. (2020) Cell research 30, 623-625. PMID: 32203132 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human ABCB11 Antibody (SAA1534)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
