Anti-ABCB11 Polyclonal Antibody (HF994014)

Name: Anti-ABCB11 Polyclonal Antibody
Brand: abinScience
SKU: HF994014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HF994014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ABCB11 (Glu421-Ala663).

Target

BSEP, Bile salt export pump, ABCB11, ATP-binding cassette sub-family B member 11

Purification

Purified by antigen affinity column.

Accession

O95342

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Bile salt export pump (ABCB11) is a ~146 kDa protein. Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion.

1. Hayashi, H. et al. (2005) Hepatology (Baltimore, Md.) 41, 916-24. PMID: 15791618

2. Hayashi, H. et al. (2005) Biochimica et biophysica acta 1738, 54-62. PMID: 16332456

3. Yabuuchi, H. et al. (2008) Biopharmaceutics & drug disposition 29, 441-8. PMID: 18985798

4. Paulusma, CC. et al. (2009) The Journal of biological chemistry 284, 9947-54. PMID: 19228692

5. Ho, RH. et al. (2010) Pharmacogenetics and genomics 20, 45-57. PMID: 20010382

6. Kato, T. et al. (2010) Biochimica et biophysica acta 1801, 1005-12. PMID: 20398791

7. Hayashi, H. et al. (2012) Hepatology (Baltimore, Md.) 55, 1889-900. PMID: 22262466

8. Guyot, C. et al. (2014) Molecular pharmacology 85, 909-20. PMID: 24711118

9. Imagawa, K. et al. (2018) Journal of human genetics 63, 569-577. PMID: 29507376

10. Wang, L. et al. (2020) Cell research 30, 623-625. PMID: 32203132

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-ABCB11 polyclonal antibody at 1ug/mL on recombinant ABCB11 (Catalog No. HF994012).

References

Datasheet

Anti-ABCB11 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-ABCB11 Polyclonal Antibody (HF994014)

Overview

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References

Datasheet

SDS

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