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| カタログ番号 | HV352014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ABCC2 Polyclonal Antibody (HV352014) is a rabbit polyclonal antibody detecting ABCC2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ABCC2 (Ile1300-Glu1534). | ||||||||
| ターゲット | ATP-binding cassette sub-family C member 2, Multidrug resistance-associated protein 2, Canalicular multispecific organic anion transporter 1, ABCC2, CMOAT, Canalicular multidrug resistance protein, MRP2, CMRP, CMOAT1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q92887 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | ATP-binding cassette sub-family C member 2 (ABCC2) is a ~174 kDa protein. ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification. Also mediates hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Transports sulfated bile salt such as taurolithocholate sulfate. 1. Cui, Y. et al. (1999) Molecular pharmacology 55, 929-37. PMID: 10220572 2. Kamisako, T. et al. (1999) Hepatology (Baltimore, Md.) 30, 485-90. PMID: 10421658 3. Ito, K. et al. (2001) The Journal of biological chemistry 276, 38108-14. PMID: 11500505 4. Hayashi, H. et al. (2005) Biochimica et biophysica acta 1738, 54-62. PMID: 16332456 5. Huisman, MT. et al. (2002) AIDS (London, England) 16, 2295-301. PMID: 12441801 | ||||||||
| 注意事項 | For research use only. |
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