Human ABCC2 Recombinant Protein (N-His) (HV352012)

Name: Human ABCC2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HV352012
Price: 211 USD
Availability: InStock

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Catalog No.	HV352012
Description	Recombinant Human ABCC2 Protein, N-His (HV352012) expressed in E. coli, spanning Ile1300-Glu1534. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q92887
Protein length	Ile1300-Glu1534
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	28.21 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. RECONSTITUTION PROTOCOL 1. Allow the product to be reconstituted and the reconstitution diluent to reach room temperature. 2. Tap or briefly centrifuge the product vial before opening to dislodge any lyophilized material that may be dispersed on the wall or cap of the vial. 3. Use the diluent and stock concentration recommended in the product datasheet. If preparing a stock concentration higher than recommended, contact Technical Service. 4. After adding the diluent, re-cap the vial and invert gently by hand or place on a slow rocking platform to allow the reconstitution diluent to coat all the surfaces inside the vial. Note: Do not mix by vortexing or by pipetting the material up and down. 5. Allow the vial to sit at room temperature with gentle agitation for at least 15 minutes before aliquotting or using. 6. Store the reconstituted material in single use aliquots in polypropylene or siliconized tubes. Aliquots of 10 μL or larger are recommended.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ATP-binding cassette sub-family C member 2, Multidrug resistance-associated protein 2, Canalicular multispecific organic anion transporter 1, ABCC2, CMOAT, Canalicular multidrug resistance protein, MRP2, CMRP, CMOAT1
Background	ATP-binding cassette sub-family C member 2 (ABCC2) is a ~174 kDa protein. ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification. Also mediates hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Transports sulfated bile salt such as taurolithocholate sulfate. 1. Cui, Y. et al. (1999) Molecular pharmacology 55, 929-37. PMID: 10220572 2. Kamisako, T. et al. (1999) Hepatology (Baltimore, Md.) 30, 485-90. PMID: 10421658 3. Ito, K. et al. (2001) The Journal of biological chemistry 276, 38108-14. PMID: 11500505 4. Hayashi, H. et al. (2005) Biochimica et biophysica acta 1738, 54-62. PMID: 16332456 5. Huisman, MT. et al. (2002) AIDS (London, England) 16, 2295-301. PMID: 12441801
Note	For research use only.

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SDS-PAGE for Recombinant Human ABCC2 Protein, N-His

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Datasheet

Human ABCC2 Recombinant Protein (N-His).pdf

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Human ABCC2 Recombinant Protein (N-His) (HV352012)

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