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| カタログ番号 | HP529013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1381 | ||||
| ターゲット | Abeta40, Beta-APP40, Amyloid-beta protein 40, amyloid beta A4 precursor protein, Amyloid-beta A4 protein | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P05067 | ||||
| RRID | Anti-Human Abeta40/Beta-APP40 Antibody (SAA1381) (abinScience Cat# HP529013, RRID:AB_3726900) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Amyloid-beta precursor protein (Abeta 40/Beta-APP 40) is a ~86 kDa protein. Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP. _x005F_x005F_x000D_ _x005F_x005F_x000D_1. Baumkötter, F. et al. (2014) The Journal of neuroscience : the official journal of the Society for Neuroscience 34, 11159-72. PMID: 25122912 _x005F_x005F_x000D_
_x005F_x005F_x000D_
2. Satpute-Krishnan, P. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 16532-7. PMID: 17062754 _x005F_x005F_x000D_
_x005F_x005F_x000D_
3. Seamster, PE. et al. (2012) Physical biology 9, 055005. PMID: 23011729 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human Abeta40/Beta-APP40 Antibody (SAA1381).
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