Anti-Human APP Recombinant Antibody (21F12) (HP849013)

Name: Anti-Human APP Recombinant Antibody (21F12)
Brand: abinScience
SKU: HP849013
Price: 126 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HP849013

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Mouse

Isotype

IgG1

Clone ID

21F12

Clonality

Monoclonal

Target

Abeta42, Beta-APP42, Amyloid-beta protein 42, amyloid beta A4 precursor protein, Amyloid-beta A4 protein

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P05067

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Amyloid-beta precursor protein (Abeta 42/Beta-APP 42) is a ~86 kDa protein. Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP.

1. Baumkötter, F. et al. (2014) The Journal of neuroscience : the official journal of the Society for Neuroscience 34, 11159-72. PMID: 25122912

2. Satpute-Krishnan, P. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 16532-7. PMID: 17062754

3. Seamster, PE. et al. (2012) Physical biology 9, 055005. PMID: 23011729

Note

For research use only.

Images

Bioactivity

SEC-HPLC detection for Anti-Human Abeta42/Beta-APP42 Antibody (21F12).
SDS-PAGE

SDS-PAGE for Anti-Human Abeta42/Beta-APP42 Antibody (21F12).