Anti-Human Abeta42/Beta-APP42 Recombinant Antibody (21F12), PerCP (HP849143)

Name: Anti-Human Abeta42/Beta-APP42 Recombinant Antibody (21F12), PerCP
Brand: abinScience
SKU: HP849143
Price: 268 USD
Availability: InStock

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Número de catálogo	HP849143
Reactividad de especies	Human
Aplicaciones	FCM
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG1
ID de clon	21F12
Conjugación	PerCP
Objetivo	Abeta42, Beta-APP42, Amyloid-beta protein 42, amyloid beta A4 precursor protein, Amyloid-beta A4 protein, Abeta 1-42
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Productos asociados	Mouse IgG1 Recombinant Isotype Control Antibody (HyHEL-10), PerCP
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P05067
RRID	Anti-Human Abeta42/Beta-APP42 Antibody (21F12), PerCP (abinScience Cat# HP849143, RRID:AB_3725381)
Forma	Liquid
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Estabilidad y almacenamiento	The antibody solution should be stored between 2 to 8°C in dark. DO NOT FREEZE!
Fondo	Amyloid-beta precursor protein (Abeta 42/Beta-APP 42) is a ~86 kDa protein. Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP. 1. Baumkötter, F. et al. (2014) The Journal of neuroscience : the official journal of the Society for Neuroscience 34, 11159-72. PMID: 25122912 2. Satpute-Krishnan, P. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 16532-7. PMID: 17062754 3. Seamster, PE. et al. (2012) Physical biology 9, 055005. PMID: 23011729
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.