Anti-Human Abeta42/Beta-APP42 Recombinant Antibody (21F12), PerCP (HP849143)

Name: Anti-Human Abeta42/Beta-APP42 Recombinant Antibody (21F12), PerCP
Brand: abinScience
SKU: HP849143
Price: 268 USD
Availability: InStock

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概要
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参考文献
データシート
SDS

概要

カタログ番号	HP849143
種反応性	Human
アプリケーション	FCM
宿主種	Mouse
クローン性	Monoclonal
アイソタイプ	IgG1
クローンID	21F12
抱合	PerCP
ターゲット	Abeta42, Beta-APP42, Amyloid-beta protein 42, amyloid beta A4 precursor protein, Amyloid-beta A4 protein, Abeta 1-42
エンドトキシンレベル	Please contact with the lab for this information.
純度	>95% as determined by SDS-PAGE.
関連製品	Mouse IgG1 Recombinant Isotype Control Antibody (HyHEL-10), PerCP
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P05067
RRID	Anti-Human Abeta42/Beta-APP42 Antibody (21F12), PerCP (abinScience Cat# HP849143, RRID:AB_3725381)
形態	Liquid
保存バッファー	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
再構成	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
安定性と保存	The antibody solution should be stored between 2 to 8°C in dark. DO NOT FREEZE!
背景	Amyloid-beta precursor protein (Abeta 42/Beta-APP 42) is a ~86 kDa protein. Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP. 1. Baumkötter, F. et al. (2014) The Journal of neuroscience : the official journal of the Society for Neuroscience 34, 11159-72. PMID: 25122912 2. Satpute-Krishnan, P. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 16532-7. PMID: 17062754 3. Seamster, PE. et al. (2012) Physical biology 9, 055005. PMID: 23011729
注意事項	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.