Anti-Human ACAD9 Polyclonal Antibody (HP164014)

Name: Anti-Human ACAD9 Polyclonal Antibody
Brand: abinScience
SKU: HP164014
Price: 168 USD
Availability: InStock

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50ug
100ug

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Número de catálogo

HP164014

Descripción

Anti-Human ACAD9 Polyclonal Antibody (HP164014) is a rabbit polyclonal antibody detecting ACAD9 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human ACAD9 (Thr11-Asn429).

Objetivo

ACAD9, Acyl-CoA dehydrogenase family member 9, ACAD-9, Complex I assembly factor ACAD9, mitochondrial

Purificación

Purified by antigen affinity column.

Número de acceso

Q9H845

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Complex I assembly factor ACAD9, mitochondrial is a ~68 kDa protein. Together with NDUFAF1 and ECSIT, forms part of the mitochondrial complex I (MCIA),which is required for the biogenesis of respiratory Complex I (CI) and is therefore crucial for the activation of the oxidative phosphorylation system. ECSIT binding triggers a large conformational change, switching ACAD9 from a fatty acid oxidation (FAO) enzyme to a CI assembly factor. The function in CI assembly is independent of the FAO activity of the protein. As FAO enzyme, it catalyzes the first step in FAO, which consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Its preferred substrates are both saturated and unsaturated long-chain acyl-CoA substrates, with optimum activity toward the latter.

1. Nouws, J. et al. (2010) Cell metabolism 12, 283-94. PMID: 20816094

2. Nouws, J. et al. (2014) Human molecular genetics 23, 1311-9. PMID: 24158852

3. Formosa, LE. et al. (2020) Cell reports 31, 107541. PMID: 32320651

4. McGregor, L. et al. (2023) Nature communications 14, 8248. PMID: 38086790

5. Zhang, J. et al. (2002) Biochemical and biophysical research communications 297, 1033-42. PMID: 12359260

6. Ensenauer, R. et al. (2005) The Journal of biological chemistry 280, 32309-16. PMID: 16020546

7. He, M. et al. (2007) American journal of human genetics 81, 87-103. PMID: 17564966

8. He, M. et al. (2011) Molecular genetics and metabolism 102, 418-29. PMID: 21237683

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human ACAD9 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Human ACAD9 Polyclonal Antibody (HP164014)

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Referencias

Datasheet

SDS