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| カタログ番号 | HP164014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ACAD9 Polyclonal Antibody (HP164014) is a rabbit polyclonal antibody detecting ACAD9 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ACAD9 (Thr11-Asn429). | ||||||||
| ターゲット | ACAD9, Acyl-CoA dehydrogenase family member 9, ACAD-9, Complex I assembly factor ACAD9, mitochondrial | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9H845 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Complex I assembly factor ACAD9, mitochondrial is a ~68 kDa protein. Together with NDUFAF1 and ECSIT, forms part of the mitochondrial complex I (MCIA),which is required for the biogenesis of respiratory Complex I (CI) and is therefore crucial for the activation of the oxidative phosphorylation system. ECSIT binding triggers a large conformational change, switching ACAD9 from a fatty acid oxidation (FAO) enzyme to a CI assembly factor. The function in CI assembly is independent of the FAO activity of the protein. As FAO enzyme, it catalyzes the first step in FAO, which consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Its preferred substrates are both saturated and unsaturated long-chain acyl-CoA substrates, with optimum activity toward the latter. 1. Nouws, J. et al. (2010) Cell metabolism 12, 283-94. PMID: 20816094 2. Nouws, J. et al. (2014) Human molecular genetics 23, 1311-9. PMID: 24158852 3. Formosa, LE. et al. (2020) Cell reports 31, 107541. PMID: 32320651 4. McGregor, L. et al. (2023) Nature communications 14, 8248. PMID: 38086790 5. Zhang, J. et al. (2002) Biochemical and biophysical research communications 297, 1033-42. PMID: 12359260 6. Ensenauer, R. et al. (2005) The Journal of biological chemistry 280, 32309-16. PMID: 16020546 7. He, M. et al. (2007) American journal of human genetics 81, 87-103. PMID: 17564966 8. He, M. et al. (2011) Molecular genetics and metabolism 102, 418-29. PMID: 21237683 | ||||||||
| 注意事項 | For research use only. |
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