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Anti-Human ADGRG3 Polyclonal Antibody (HA966024)

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Número de catálogoHA966024
Descripción
Anti-Human ADGRG3 Polyclonal Antibody (HA966024) is a rabbit polyclonal antibody detecting ADGRG3. Suitable for Human.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human ADGRG3 (2*(Gly396-Thr434)).
Objetivo ADGRG3, ADGRG3 C-terminal fragment, ADGRG3 N-terminal fragment, Adhesion G protein-coupled receptor G3, Adhesion G-protein coupled receptor G3, C-terminal fragment, Adhesion G-protein coupled receptor G3, N-terminal fragment, G-protein coupled receptor 97, GPR97, PGR26
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso Q86Y34
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

Adhesion G protein-coupled receptor G3 (ADGRG3) is a ~60 kDa protein. Adhesion G-protein coupled receptor (aGPCR) for glucocorticoid hormones such as cortisol, cortisone and 11-deoxycortisol. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG3/GPR97 is coupled to G(o)/GNAO1 G proteins and mediates signaling by inhibiting adenylate cyclase activity. May also signal through G-alpha(q)-proteins; additional evidence are however required to confirm this result in vivo. Plays a role in the regulation of various processes including B-cell development, inflammation or innate immunity.

1. Ping, YQ. et al. (2021) Nature 589, 620-626. PMID: 33408414
2. Gupte, J. et al. (2012) FEBS letters 586, 1214-9. PMID: 22575658
3. Hsiao, CC. et al. (2018) Frontiers in immunology 9, 2830. PMID: 30559745
4. Chu, TY. et al. (2022) Nature communications 13, 6385. PMID: 36302784
5. Valtcheva, N. et al. (2013) The Journal of biological chemistry 288, 35736-48. PMID: 24178298
Nota For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human ADGRG3 Polyclonal Antibody

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