Human ADGRG3 Recombinant Protein (N-His) (HA966022)

Name: Human ADGRG3 Recombinant Protein (N-His)
Brand: abinScience
SKU: HA966022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HA966022
Description	Recombinant Human ADGRG3 Protein, N-His (HA966022) expressed in E. coli. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q86Y34
Protein length	2*(Gly396-Thr434)
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	13.03 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ADGRG3, ADGRG3 C-terminal fragment, ADGRG3 N-terminal fragment, Adhesion G protein-coupled receptor G3, Adhesion G-protein coupled receptor G3, C-terminal fragment, Adhesion G-protein coupled receptor G3, N-terminal fragment, G-protein coupled receptor 97, GPR97, PGR26
Background	Adhesion G protein-coupled receptor G3 is a ~60 kDa protein. Adhesion G-protein coupled receptor (aGPCR) for glucocorticoid hormones such as cortisol, cortisone and 11-deoxycortisol. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG3/GPR97 is coupled to G(o)/GNAO1 G proteins and mediates signaling by inhibiting adenylate cyclase activity. May also signal through G-alpha(q)-proteins; additional evidence are however required to confirm this result in vivo. Plays a role in the regulation of various processes including B-cell development, inflammation or innate immunity. 1. Ping, YQ. et al. (2021) Nature 589, 620-626. PMID: 33408414 2. Gupte, J. et al. (2012) FEBS letters 586, 1214-9. PMID: 22575658 3. Hsiao, CC. et al. (2018) Frontiers in immunology 9, 2830. PMID: 30559745 4. Chu, TY. et al. (2022) Nature communications 13, 6385. PMID: 36302784 5. Valtcheva, N. et al. (2013) The Journal of biological chemistry 288, 35736-48. PMID: 24178298
Note	For research use only

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Datasheet

Human ADGRG3 Recombinant Protein (N-His).pdf

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Human ADGRG3 Recombinant Protein (N-His) (HA966022)

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