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Anti-Human beta-1 Adrenergic R/ADRB1 Polyclonal Antibody (HY486014)

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Vista general
Número de catálogoHY486014
Descripción
Anti-Human ADRB1 Polyclonal Antibody (HY486014) is a rabbit polyclonal antibody detecting ADRB1. Suitable for Human.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human ADRB1 (Gly2-Gln55&His197-Arg222).
Objetivo ADRB1, ADRB1R, B1AR, Beta-1 adrenergic receptor, Beta-1 adrenoceptor, Beta-1 adrenoreceptor
Nivel de endotoxinas Please contact with the lab for this information.
Pureza >95% as determined by SDS-PAGE.
Purificación Purified by antigen affinity column.
Número de acceso P08588
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

Beta-1 adrenergic receptor (ADRB1) is a ~51 kDa protein. G protein-coupled receptor for catecholamines that couples to G(s) proteins to activate adenylate cyclase and cAMP-dependent pathway. Binds epinephrine and norepinephrine with approximately equal affinity. Mediates the activation of Ras via binding with cAMP-dependent RAPGEF2. As part of the sympathetic nervous system, plays a role in the physiologic regulation of cardiac functions such as stimulation of cardiomyocyte contraction. Also delivers proapoptotic signals in cardiomyocytes.

1. Mason, DA. et al. (1999) The Journal of biological chemistry 274, 12670-4. PMID: 10212248
2. Pak, Y. et al. (2002) Molecular and cellular biology 22, 7942-52. PMID: 12391161
3. He, J. et al. (2004) The Journal of biological chemistry 279, 50190-6. PMID: 15358775
4. Xu, X. et al. (2021) Cell research 31, 569-579. PMID: 33093660
5. Börjesson, M. et al. (2000) European heart journal 21, 1853-8. PMID: 11052857
6. Ranade, K. et al. (2002) American journal of human genetics 70, 935-42. PMID: 11854867
7. Shi, G. et al. (2019) Neuron 103, 1044-1055.e7. PMID: 31473062
Nota For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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