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Anti-Human beta-1 Adrenergic R/ADRB1 Polyclonal Antibody (HY486014)

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Aperçu
Numéro de catalogueHY486014
Description
Anti-Human ADRB1 Polyclonal Antibody (HY486014) is a rabbit polyclonal antibody detecting ADRB1. Suitable for Human.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human ADRB1 (Gly2-Gln55&His197-Arg222).
Cible ADRB1, ADRB1R, B1AR, Beta-1 adrenergic receptor, Beta-1 adrenoceptor, Beta-1 adrenoreceptor
Niveau d'endotoxines Please contact with the lab for this information.
Pureté >95% as determined by SDS-PAGE.
Purification Purified by antigen affinity column.
Numéro d'accès P08588
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Contexte

Beta-1 adrenergic receptor (ADRB1) is a ~51 kDa protein. G protein-coupled receptor for catecholamines that couples to G(s) proteins to activate adenylate cyclase and cAMP-dependent pathway. Binds epinephrine and norepinephrine with approximately equal affinity. Mediates the activation of Ras via binding with cAMP-dependent RAPGEF2. As part of the sympathetic nervous system, plays a role in the physiologic regulation of cardiac functions such as stimulation of cardiomyocyte contraction. Also delivers proapoptotic signals in cardiomyocytes.

1. Mason, DA. et al. (1999) The Journal of biological chemistry 274, 12670-4. PMID: 10212248
2. Pak, Y. et al. (2002) Molecular and cellular biology 22, 7942-52. PMID: 12391161
3. He, J. et al. (2004) The Journal of biological chemistry 279, 50190-6. PMID: 15358775
4. Xu, X. et al. (2021) Cell research 31, 569-579. PMID: 33093660
5. Börjesson, M. et al. (2000) European heart journal 21, 1853-8. PMID: 11052857
6. Ranade, K. et al. (2002) American journal of human genetics 70, 935-42. PMID: 11854867
7. Shi, G. et al. (2019) Neuron 103, 1044-1055.e7. PMID: 31473062
Note For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
Recommandation

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