

| Numéro de catalogue | HC599014 | ||||||||
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| Description |
Anti-Human AIMP2 Polyclonal Antibody (HC599014) is a rabbit polyclonal antibody detecting AIMP2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Cricetulus griseus.
Highlights
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human AIMP2 (Lys120-Lys320). | ||||||||
| Cible | Protein JTV-1, Multisynthase complex auxiliary component p38, AIMP2, JTV1, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q13155 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) is a ~35 kDa protein. Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. 1. Kaminska, M. et al. (2009) The Journal of biological chemistry 284, 6053-60. PMID: 19131329 | ||||||||
| Note | For research use only. |
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