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| カタログ番号 | HC599014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human AIMP2 Polyclonal Antibody (HC599014) is a rabbit polyclonal antibody detecting AIMP2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Cricetulus griseus.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human AIMP2 (Lys120-Lys320). | ||||||||
| ターゲット | Protein JTV-1, Multisynthase complex auxiliary component p38, AIMP2, JTV1, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13155 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) is a ~35 kDa protein. Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. 1. Kaminska, M. et al. (2009) The Journal of biological chemistry 284, 6053-60. PMID: 19131329 | ||||||||
| 注意事項 | For research use only. |
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