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| カタログ番号 | HA840023 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA, IF, IP | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a | ||||
| クローンID | SAA2124 | ||||
| ターゲット | ANAPC2, anaphase promoting complex subunit 2 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q9UJX6 | ||||
| RRID | Anti-Human ANAPC2 Antibody (SAA2124) (abinScience Cat# HA840023, RRID:AB_3729476) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Anaphase-promoting complex subunit 2 (ANAPC2) is a ~93 kDa protein. Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation. 1. Tang, Z. et al. (2001) Molecular biology of the cell 12, 3839-51. PMID: 11739784 2. Jin, L. et al. (2008) Cell 133, 653-65. PMID: 18485873 3. Yau, RG. et al. (2017) Cell 171, 918-933.e20. PMID: 29033132 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human ANAPC2 Antibody (SAA2124)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
