Anti-Human ANAPC2 Recombinant Antibody (SAA2123) (HA840013)

Name: Anti-Human ANAPC2 Recombinant Antibody (SAA2123)
Brand: abinScience
SKU: HA840013
Price: 191 USD
Availability: InStock

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1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HA840013

Species reactivity

Human

Applications

ELISA, IF, IP

Host species

Mouse

Clonality

Monoclonal

Isotype

IgG2a

Clone ID

SAA2123

Target

ANAPC2, anaphase promoting complex subunit 2

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9UJX6

RRID

Anti-Human ANAPC2 Antibody (SAA2123) (abinScience Cat# HA840013, RRID:AB_3729475)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Anaphase-promoting complex subunit 2 (ANAPC2) is a ~93 kDa protein. Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.

1. Tang, Z. et al. (2001) Molecular biology of the cell 12, 3839-51. PMID: 11739784

2. Jin, L. et al. (2008) Cell 133, 653-65. PMID: 18485873

3. Yau, RG. et al. (2017) Cell 171, 918-933.e20. PMID: 29033132

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human ANAPC2 Antibody (SAA2123)

References

Datasheet

Anti-Human ANAPC2 Recombinant Antibody (SAA2123).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human ANAPC2 Recombinant Antibody (SAA2123) (HA840013)

Overview

Images

References

Datasheet

SDS

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