Anti-Human ANO1 Polyclonal Antibody (HP641014)

Name: Anti-Human ANO1 Polyclonal Antibody
Brand: abinScience
SKU: HP641014
Price: 96 USD
Availability: InStock

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Vista general
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Referencias
Datasheet
SDS

Vista general

Número de catálogo

HP641014

Reactividad de especies

Human, Mouse

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human ANO1 (Met117-Gly325).

Objetivo

Anoctamin-1, Tumor-amplified and overexpressed sequence 2, Transmembrane protein 16A, Discovered on gastrointestinal stromal tumors protein 1, Oral cancer overexpressed protein 2, TMEM16A, ANO1, TAOS2, ORAOV2, DOG1

Purificación

Purified by antigen affinity column.

Número de acceso

Q5XXA6

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Anoctamin-1 (ANO1/TMEM16A) is a ~114 kDa protein. Calcium-activated chloride channel (CaCC). Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca(2+) store release and is also required for CFTR membrane expression.

1. Schreiber, R. et al. (2010) The Journal of biological chemistry 285, 7838-45. PMID: 20056604

2. Ousingsawat, J. et al. (2011) Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 28, 715-24. PMID: 22178883

3. Tian, Y. et al. (2012) Journal of cell science 125, 4991-8. PMID: 22946059

4. Park, JH. et al. (2021) Journal of medical genetics 58, 247-253. PMID: 32487539

5. Benedetto, R. et al. (2017) Scientific reports 7, 12397. PMID: 28963502

6. Cabrita, I. et al. (2021) American journal of respiratory cell and molecular biology 64, 50-58. PMID: 33026825

7. Simões, FB. et al. (2019) Life science alliance 2. PMID: 31732694

Nota

For research use only.

Imágenes