Anti-Human ANO1 Monoclonal Antibody (1A606) (HP641015)

Name: Anti-Human ANO1 Monoclonal Antibody (1A606)
Brand: abinScience
SKU: HP641015
Price: 106 USD
Availability: InStock

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Overview

Catalog No.	HP641015
Description	Anti-Human ANO1 Monoclonal Antibody (1A606) [1A606] (HP641015) is a mouse monoclonal antibody detecting ANO1 in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	ELISA, IHC, WB
Host species	Mouse
Clonality	Monoclonal
Isotype	IgG
Clone ID	1A606
Immunogen	E. coli - derived recombinant human ANO1 (Met117-Gly325).
Target	Anoctamin-1, Discovered on gastrointestinal stromal tumors protein 1, Oral cancer overexpressed protein 2, Transmembrane protein 16A, Tumor-amplified and overexpressed sequence 2, ANO1
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q5XXA6
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Anoctamin-1 (ANO1) is a ~114 kDa protein. Calcium-activated chloride channel (CaCC). Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca(2+) store release and is also required for CFTR membrane expression. 1. Schreiber, R. et al. (2010) The Journal of biological chemistry 285, 7838-45. PMID: 20056604 2. Ousingsawat, J. et al. (2011) Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 28, 715-24. PMID: 22178883 3. Tian, Y. et al. (2012) Journal of cell science 125, 4991-8. PMID: 22946059 4. Park, JH. et al. (2021) Journal of medical genetics 58, 247-253. PMID: 32487539 5. Benedetto, R. et al. (2017) Scientific reports 7, 12397. PMID: 28963502 6. Cabrita, I. et al. (2021) American journal of respiratory cell and molecular biology 64, 50-58. PMID: 33026825 7. Simões, FB. et al. (2019) Life science alliance 2. PMID: 31732694
Note	For research use only.