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Anti-Human APH1A Polyclonal Antibody (HP487014)

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Vista general
Número de catálogoHP487014
Descripción
Anti-Human APH1A Polyclonal Antibody (HP487014) is a rabbit polyclonal antibody detecting APH1A in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human APH1A (Asn207-Asp265).
Objetivo Gamma-secretase subunit APH-1A, PSF, Presenilin-stabilization factor, APH-1a, APH1A, Aph-1alpha
Purificación Purified by antigen affinity column.
Número de acceso Q96BI3
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Gamma-secretase subunit APH-1A (APH1A) is a ~28 kDa protein. Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Required for normal gamma-secretase assembly. The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable).

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3. Edbauer, D. et al. (2003) Nature cell biology 5, 486-8. PMID: 12679784
4. Marlow, L. et al. (2003) Biochemical and biophysical research communications 305, 502-9. PMID: 12763021
5. Lu, P. et al. (2014) Nature 512, 166-170. PMID: 25043039
6. Bai, XC. et al. (2015) Nature 525, 212-217. PMID: 26280335
7. Yang, G. et al. (2019) Nature 565, 192-197. PMID: 30598546
8. Zhou, R. et al. (2019) Science (New York, N.Y.) 363. PMID: 30630874
9. Gu, Y. et al. (2003) The Journal of biological chemistry 278, 7374-80. PMID: 12471034
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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