Please ensure Javascript is enabled for purposes of website accessibility
Contactez-nous Contactez-nous
FR
Accueil > Products > Anticorps > Anticorps Primaires

Anti-Human APH1A Polyclonal Antibody (HP487014)

Fiche technique Partager le produit Copier les informations
Prix(USD) : --
Spécification :
  • 50ug
  • 100ug
Nombre :
Contactez-nous

  • Aperçu

  • Images

  • Reférences

  • Fiche technique

  • SDS

Aperçu
Numéro de catalogueHP487014
Description
Anti-Human APH1A Polyclonal Antibody (HP487014) is a rabbit polyclonal antibody detecting APH1A in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human APH1A (Asn207-Asp265).
Cible Gamma-secretase subunit APH-1A, PSF, Presenilin-stabilization factor, APH-1a, APH1A, Aph-1alpha
Purification Purified by antigen affinity column.
Numéro d'accès Q96BI3
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Gamma-secretase subunit APH-1A (APH1A) is a ~28 kDa protein. Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Required for normal gamma-secretase assembly. The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable).

1. Lee, SF. et al. (2002) The Journal of biological chemistry 277, 45013-9. PMID: 12297508
2. Luo, WJ. et al. (2003) The Journal of biological chemistry 278, 7850-4. PMID: 12522139
3. Edbauer, D. et al. (2003) Nature cell biology 5, 486-8. PMID: 12679784
4. Marlow, L. et al. (2003) Biochemical and biophysical research communications 305, 502-9. PMID: 12763021
5. Lu, P. et al. (2014) Nature 512, 166-170. PMID: 25043039
6. Bai, XC. et al. (2015) Nature 525, 212-217. PMID: 26280335
7. Yang, G. et al. (2019) Nature 565, 192-197. PMID: 30598546
8. Zhou, R. et al. (2019) Science (New York, N.Y.) 363. PMID: 30630874
9. Gu, Y. et al. (2003) The Journal of biological chemistry 278, 7374-80. PMID: 12471034
Note For research use only.
Images
Reférences
Fiche technique
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
Recommandation

Contactez-nous pour les devis personnalisés, les demandes en gros et tout autre problème.

Courrier : [email protected]

Liste des distributeurs

Obtenir un devis gratuit
Anti-Human APH1A Polyclonal Antibody

Accès rapide

Contactez-nous

  • +86-027-65523339

  • [email protected]

  • Bâtiment C, No. 666, Rue Shendunsi, Wuhan, 430206, Chine

  • linkedin
  • Ins
  • youtube
  • youtube
Droit d'auteur © 2026 abinScience. Tous droits réservés. Tous les produits sont uniquement à usage de recherche