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| カタログ番号 | HB477014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human APOBEC3H Polyclonal Antibody (HB477014) is a rabbit polyclonal antibody detecting DNA dC->dU-editing enzyme APOBEC-3H; 3.5.4.38; APOBEC-related protein 10; ARP-10; Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H; A3H; APOBEC3H in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human APOBEC3H (Met1-Val200). | ||||||||
| ターゲット | DNA dC->dU-editing enzyme APOBEC-3H; 3.5.4.38; APOBEC-related protein 10; ARP-10; Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H; A3H; APOBEC3H | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q6NTF7 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | DNA dC->dU-editing enzyme APOBEC-3H (APOBEC3H) is a ~23 kDa protein. DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. 1. OhAinle, M. et al. (2006) Journal of virology 80, 3853-62. PMID: 16571802 2. Dang, Y. et al. (2006) Journal of virology 80, 10522-33. PMID: 16920826 3. OhAinle, M. et al. (2008) Cell host & microbe 4, 249-59. PMID: 18779051 4. Tan, L. et al. (2009) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23, 279-87. PMID: 18827027 5. Stenglein, MD. et al. (2010) Nature structural & molecular biology 17, 222-9. PMID: 20062055 6. Phalora, PK. et al. (2012) Journal of virology 86, 11712-24. PMID: 22915799 7. Shaban, NM. et al. (2018) Molecular cell 69, 75-86.e9. PMID: 29290613 8. Dang, Y. et al. (2008) The Journal of biological chemistry 283, 11606-14. PMID: 18299330 9. Hultquist, JF. et al. (2011) Journal of virology 85, 11220-34. PMID: 21835787 10. Chaipan, C. et al. (2013) Journal of virology 87, 444-53. PMID: 23097438 | ||||||||
| 注意事項 | For research use only |
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